Behavioural observations in gunn rats

Xenotransplantation of hamster liver into Gunn rats reserves congenital hyperbilirubinemia.

THE Gunn rat is an animal model for Crigler-Najar syndrome. a rare form of congenital unconjugated nonhemolytic hyperbilirubinemia due to the absence of glucoronyl transferase. I.e It leads to deposition of bilirubin in the basal ganglia. culminating in precocious death of the patient. Because the uptake. conjugation. and excretion of bilirubin by hepatocytes involves specific carriers and enzy...

Behavioural consequences of hypergravity in developing rats.

Gravity represents a stable reference for the nervous system. When the individual is increasing in size and weight, gravity may influence several aspects of the sensory and motor developments. To clarify this role, we studied age-dependent modifications of several exteroceptive and proprioceptive reflexes in five groups of rats conceived, born and reared in hypergravity (2 g). Rats were transfe...

Gunn Effect in Compound Semiconductors

A theoretical and experimental study of the Gunn effect is presented. It appears that this effect, originally observed by Gunn as a time variation in the current through ohmic samples of n-GaAs when the sample voltage exceeded a critical value, can be accounted for by the transferred electron model of Ridley and Watkins. This model is based on a transfer of electrons from a low-mass, high-mobil...

Correction of congenital hyperbilirubinemia in homozygous Gunn rats by xenotransplantation of hamster livers.

The homozygous Gunn(j/j) rat is an animal model for Crigler-Najjarsyndrome in which the lack of the enzyme uridine diphosphoglucoronate-glucuronosyltransferase (UDP-GT) results in congenital unconjugated nonhemolytic hyperbilirubinemia. Because the binding of bilirubin to albumin in plasma varies from species to species, xenotransplantation (XTx) of liver afforded in this model the opportunity ...

PS147. Gunn rats show depression-like behavior and microglial activation in the hippocampus